Purpose: Antiseptic. Benzalkonium chloride has repeatedly demonstrated its toxic characteristics in laboratory, experimental, and clinical studies. Effects of short-term exposure, Benzethonium chloride is corrosive to the eyes and is irritating to the skin. Long-term effects from repeated exposure may cause dermatitis. Benzalkonium chloride is found in many household disinfectants and cleaning supplies. The ingredient is used in cosmetic products as a foaming cleansing and bactericidal agent at concentrations up to 5.0%. This article discusses benzalkonium chloride, within the context of its historical and clinical significance in association with its use in antiseptics, cosmetics, detergents, and topical medications. SAFETY DATA SHEET - Fisher Sci Commission regulation (EU) no. In case of contact with eyes, flush thoroughly with water. Benzalkonium chloride (BKC) is a quaternary ammonium antimicrobial agent included in some nasal solutions (including glucocorticosteroids) to prevent the growth of bacteria. 1620 L St NW Suite 1200 Washington DC 20036-4702 phone: 202-331-0651 fax: 202-331-0088 Identification Product Name Benzalkonium chloride, 50 wt% aqueous solution Cat No. 2 As reported … Analytical Method Development and Validation of ... Benzalkonium Chloride - an overview | ScienceDirect Topics Safety Information: It was concluded that Benzalkonium Chloride can be safely used as antimicrobial agent at concentrations up to 0.1%. SAFETY DATA SHEET - Fisher Sci The American College of Toxicology has concluded that BKC can be safely used as an antimicrobial agent at concentrations up to 0.1%. The frequent, daily use of hand sanitizers containing 0.3% benzalkonium chloride may cause red, itchy, dry or scaly skin in susceptible individuals. Find Safety Data Sheets(SDS) of BENZALKONIUM CHLORIDE(CAS 68424-85-1 ) for lookchem Specs. Benzalkonium chloride solution ≥50% (via Cl), 50% in H2O; CAS Number: 63449-41-2; Synonyms: Alkylbenzyldimethylammonium chloride; find Sigma-Aldrich-63249 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1]. : C2047 CAS-No 8001-54-5 Synonyms Alkyl-benzyl-dimethylammonium chloride Recommended Use Laboratory chemicals. Wear protective gloves and eye/face protection. Benzalkonium has been in existence for over a century, and is probably the most intensely studied synthetic biocide available to man. if skin irritation develops. Drug studies Comparative studies. Benzalkonium chloride, commonly abbreviated as BZK, has wide-spread uses as an antiseptic and disinfectant. The safety of Benzalkonium Chloride has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. This product is a white waxy solid or yellow colloidal body; The aqueous solution shows a neutral or weak alkaline reaction, and produces a large amount of foam when shaking. COMPOSITION / INFORMATION OF INGREDIENTS Chemical description: Benzalkonium chloride It is a cationic surfactant used as a bactericide or preservative owing … From benzalkonium chloride-preserved latanoprost to polyquad-preserved travoprost: a 6-month study on ocular surface safety and tolerability. Scientific discussion 1. 1119/2014 of 16 October 2014 amending annex III to regulation (EC) no. Characteristics 1.1. Benzalkonium chloride itself is a mixture of very similar substances with different chain length and molecular mass. Keep ... Avoid contact with eyes. Benzalkonium chloride or BAC is an antibacterial agent belonging to the quaternary ammonium compound group. Active Ingredient. Benzethonium chloride is a (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. We're growing! A risk assessment of benzalkonium chloride (BAC) was conducted based upon its toxicological profile and exposure evaluation. Product Name & Other Names: Benzalkonium Chloride, BZK, BKC, BAC, alkyldimethylbenzylammonium chloride and ADBAC CAS No. Regular use of products containing antimicrobials such as benzalkonium chloride could leads to the development of resistant bacteria in homes and food processing facilities. Find patient medical information for benzalkonium chloride on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Certificates. The non-alcohol wipes will not harm even the most sensitive rubber facepieces. The CIR Expert Panel evaluated scientific data and concluded that Benzalkonium Chloride, at concentrations up to 0.1% free, active ingredient, was safe as a cosmetic ingredient. First-Aid Measures General Advice: Take proper precautions to ensure your own health and safety before attempting rescue and providing first aid. 1. safety data sheet 3 = high 4 = extreme hmis hazard rating safetec of america section 1 - product / company identification identity (as used on label and list) benzalkonium chloride antiseptic wipe routes of entry - signs and symptoms of exposure telephone number for information (716) 895-1822 address (number, street, p.o. SAFETY DATA SHEET Creation Date 14-Jul-2014 Revision Date 19-Jan-2018 Revision Number 4 1. It is also used as an antimicrobial preservative for pharmaceutical products. SDS. Both types are individually foil-wrapped, and measure 8" x 11". Benzalkonium Chloride Update. In addition, DDAC . May cause drowsiness or dizziness. The study was a double-masked, randomized, parallel group, multicenter, noninferiority design. Material Safety Data Sheet Product Name Benzalkonium chloride Page 3 of 13 Reduced labelling (≤125 ml) Hazard statements H314 Causes severe skin burns and eye damage. Molecular Weight: 0.00. Choice of a 70% Isopropanol wipe or a non-alcohol wipe with the active ingredient Benzalkonium Chloride. The compound was nonmuta-genic in several different cell assays. Final Report on the Safety Assessment of Benzethonium Chloride and Methylbenzethonium Chloride Benzethonium Chloride and Methylbenzethonium Chloride are quaternary ammonium salts used in cosmetics primarily as preservatives and secondarily as cationic surfactants, usually at concentrations below 1 percent. Product (s): 63449-41-2 Benzalkonium chloride solution 95%. Benzalkonium Chloride 0.12%. The US Food and Drug Administration (FDA) specifies that the safe and effective concentrations for benzethonium chloride are 0.1-0.2% in first aid products. Aqueous solutions of benzethonium chloride are not absorbed through the skin. It is not approved in the US and Europe for use as a food additive. is contained in products used as plant strengtheners. MATERIAL SAFETY DATA SHEET BENZALKONIUM CHLORIDE 1. Marketing Status: OTC monograph not final. Allergic contact dermatitis (ACD) is a socially and economically significant condition. Other CAS RN: 8001-54-5; Other UN numbers are possible, depending on manufacturers´classifications. Benzalkonium Chloride is a mixture of alkylbenzyldimethylammonium chlorides. 100/box. At the end of June, the EU Commission approved benzalkonium chloride and didecyldimethylammonium chloride as active substances for the use in biocidal products … BZK uses benzalkonium chloride as the active ingredient in our alcohol-free, benzalkonium chloride hand sanitizer. For benzalkonium chloride, we are also looking at [antimicrobial] resistance data. The ingredients are stable and less oxidized. … Benzalkonium Chloride SDS Safety Data Sheet MSDS Sheet, Material Safety Data Sheet 02-Oct-20. Benzalkonium chloride, a quaternary ammonium compound, is a mixture of several n-alkylbenzyldimethylammonium chlorides (n = 10–16) with different alkyl groups . didecyldimethylammonium chloride (DDAC) and benzalkonium chloride (BAC) were identified which exceeded the permitted legal limit of 0.01 mg/kg (default MRL established in Article 18(1)(b) of Regulation (E)C No 396/2005). It is also used as an antimicrobial preservative for pharmaceutical products. This article discusses benzalkonium chloride, within the context of its historical and clinical significance in association with its use in antiseptics, cosmetics, detergents, and topical medications. Formulation. Four non-preserved solutions were also tested. It is well-established that BAC is not genotoxic nor does it … Active Ingredient: Benzalkonium Chloride 0.24%. Material Safety Data Sheet Benzalkonium Chloride Solution, 80% MSDS 1. DSS-Induced Colitis. if skin irritation develops. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses. Material Qualification Dossier. It is widely used in the health care industry and cosmetic industry as an antimicrobial and cleansing agent. Benzalkonium chloride is inert, non-flammable, non-volatile, and good stability does not cause the risk of burning. Methods Library. Pseudoscience and Safety of Benzalkonium Chloride. An odorless antiseptic compound widely used as a disinfectant in detergents. It has been used to maintain the sterility of a variety of prescription and over-the-counter products, such as cosmetics, infant care products, and pharmaceutical nasal sprays, ophthalmic solutions, and otic drops. 396/2005 of the European Parliament and of the Council as regards maximum residue levels for benzalkonium chloride and didecyldimethylammonium chloride in or on certain products. Benzalkonium chloride (BKC) is a quaternary ammonium compound that has been in clinical use since 1935 1 as an antimicrobial additive. Benzalkonium Chloride is primarily used as a preservative and antimicrobial agent, and secondarily used as a surfactant. Benzalkonium Chloride SDS Safety Data Sheet MSDS Sheet, Material Safety Data Sheet 02-Oct-20. Ideal for use at offices, hospitals, schools, health care facilities and any other commercial, institutional and public place where there is a risk of contact with germs, bacteria and viruses. Product Identification. containing benzalkonium chloride are used for the treatment of superficial inf ections of the mouth and throat [23]. If benzalkonium chloride is swallowed, call a doctor or poison control center right away. DEA Schedule: None. Benzalkonium chloride dissociates into cationic active group in aqueous solution, which has the function of cleaning and sterilization. Avoid breathing mist or vapours. Features & Benefits. Tell your doctor if you are pregnant or plan on getting pregnant. European Commission, Brussels, Belgium. Use only outdoors or in a well-ventilated area. : 8001-54-5 or 63449-41-2 EINECS EC Code: 264-151-6 Molecular Weight: Variable. The Chemical, Biochemical & Research Essentials Supplier. It can be maintained for 4-5 hours after a single spray in public places, which can continuously kill / inhibit viruses. min for Benzalkonium Chloride-1 and Benzalkonium Chloride-2 and it was found linear (Figure 3). In case of eye contact, flush with water - Stop use and ask a doctor if irritation or redness develops. : 8001-54-5 or 63449-41-2 EINECS EC Code: 264-151-6 Molecular Weight: Variable. Wound cleansing, clean catch urine samples, and first aid kits. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Product Name: Benzalkonium chloride Company Identification: 237/2, Vellivoyal Chavadi Chennai - 600 103. DSS-Induced Colitis. Consult a physician. Personal Precautions, Protective Equipment and Emergency Procedures Operational Excellence Dossier. The store will not work correctly in the case when cookies are disabled. SAFETY DATA SHEET According to JIS Z 7253:2019 Version 2.02 Revision Date 16-Sep-2021 Section 1: PRODUCT AND COMPANY IDENTIFICATION Product name 10% Benzalkonium Chloride Solution Product code 028-05466 Manufacturer FUJIFILM Wako Pure Chemical Corporation 1-2 Doshomachi 3-Chome Ltd. Since 1935, BAC has been used in a wide variety of products such as disinfectants, preservatives, and sanitizers. Benzalkonium chloride is both a biocide and a pesticide active substance. Check out our job openings! Benzalkonium Chloride Disinfectant Wipes. Grade: Ph Eur,NF. SR0212 Personal Precautions Wear suitable gloves and eye/face protection. ... Material Safety Data Sheets. Soil Sample Preparation. Pathogenesis Etiology. In benzalkonium chloride, the common ingredient used in alcohol-free hand sanitizers, and other quaternary ammonium compounds commonly found in disinfectants, scientists unearthed a new COVID stopper. Product Name Benzalkonium chloride, 50 wt% aqueous solution Cat No. 1.Benzalkonium chloride used as disinfectant, bactericidal algicide, deodorant. SAFETY DATA SHEET According to JIS Z 7253:2019 Version 2.02 Revision Date 16-Sep-2021 Section 1: PRODUCT AND COMPANY IDENTIFICATION Product name 10% Benzalkonium Chloride Solution Product code 028-05466 Manufacturer FUJIFILM Wako Pure Chemical Corporation 1-2 Doshomachi 3-Chome Chemical Formula: Variable. Ingestion from grooming after walking over surfaces recently cleaned with a benzalkonium chloride Benzalkonium chloride -containing product (often in household disinfectants, antibacterial cleaners, mold removers, hand sanitizers, patio cleaners, etc). Benzalkonium chloride (50% aqueous solution) EMPROVE® EXPERT Ph Eur,NF - Find MSDS or SDS, a COA, data sheets and more information. It works by killing microorganisms and inhibiting their future growth, and for this reason frequently appears as an ingredient in antibacterial hand wipes, antiseptic creams and anti-itch ointments. Topical Antiseptic. When benzalkonium … Benzalkonium Chloride is a commonly used preservative in contact lens solutions and can be found as an ingredient in antimicrobial soaps, skin antiseptics, and spermicides. Dosage form: soap Ingredients: BENZALKONIUM CHLORIDE 0.13g in … Get medical attention. Nucleic Acid Extraction. Purpose: Antibacterial. Uses advised against Not for food, drug, pesticide or biocidal product … Product Name & Other Names: Benzalkonium Chloride, BZK, BKC, BAC, alkyldimethylbenzylammonium chloride and ADBAC CAS No. Benzalkonium chloride, alkyl distribution from C8H17 to C16H33 Revision Date 19-Jan-2018 Skin Contact Wash off immediately with plenty of water for at least 15 minutes. In the correct concentrations, it can kill up to 99.9% of harmful germs and bacteria. Background: Benzalkonium chloride (BAK) is a common preservative in topical ocular preparations; however, prolonged use may lead to deleterious effects on the ocular surface, affecting quality of life and reducing adherence to treatment and overall outcomes. : AC263820000; AC263820010; AC263820025 Synonyms Alkyl-benzyl-dimethylammonium chloride Recommended Use Laboratory chemicals. P301 + P330 + P331 IF SWALLOWED: Rinse mouth. A risk assessment of benzalkonium chloride (BAC) was conducted based upon its toxicological profile and exposure evaluation. Benzalkonium chloride is active at low concentrations and has been used to kill bacteria, fungi, Algae, and lichens.It does not kill spores.This type of quaternary ammonium compound has reduced effectiveness in solutions containing hard water, salts, or organic compounds. This product is easily soluble in water or ethanol, and slightly soluble in ether. Tamilnadu Office Telephone No: 044 64606747 2. 00001523 SAFETY DATA SHEET Page 2 PRODUCT: ZGB Surface Disinfectant Wipes (Benzalkonium Chloride) - 100 wipes CODE: P1-001855 SECTION 04: FIRST-AID MEASURES Indication of immediate medical attention Provide general supportive measures and treat symptomatically. It is very soluble in water, alcohol, and acetone. Benzalkonium chloride is a quaternary ammonium compound belonging to the group of cati-onic surfactants. ; Concentrations of household products vary, often between 0.2-5%. : 63449-41-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. item: model: KILLS 99.99% OF VIRUSES & BACTERIA with Benzalkonium Chloride. For most multidose aqueous nasal, ophthalmic and otic products, benzalkonium chloride is the preservative of choice. Apply now! Chemical Formula: Variable. Material name: Benzalkonium Chloride Antiseptic Wipe 2077 Version #: 01 Issue date: 01-30-2015 SDS US 3 / 7 Appropriate engineering controls Ensure adequate ventilation, especially in confined areas. Close. Show this safety data sheet to the doctor in attendance. Manufactured in the US with domestic and foreign materials to the highest quality standards. Benzalkonium chloride is widely used as a preservative in eye-drops, in higher concentrations it is used as an antiseptic and disinfectant. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. View Products on Sigmaaldrich.com. Keep out of reach of children. Label: SOOAE HAND SANITIZING WIPES- benzalkonium chloride cloth. Ideal for. Description. Latex. (A) Rabbit eye instilled twice a day with one drop of 0.01% benzalkonium chloride (BAK) for 1 and 5 months (Low Chronic model, LCm): two images (separated by a dotted red line) for each model (separated by a red line) showing the BAK distribution using MALDI-TOF mass spectrometry … The Cosmetic Ingredient Review Expert Panel, a group responsible for evaluating the safety of skincare and cosmetic ingredients has reviewed the research on benzalkonium chloride. Benzalkonium chloride is a mainstay of phase-transfer catalysis, an important technology in the synthesis of organic compounds, including drugs. ... Benzalkonium chloride is irritant to middle ear tissues at typically used concentrations. Safety Data Sheet Section 1 - Chemical Product and Company Identification Product Name Benzalkonium Chloride (BKC), 50% soln in water Product Code 43648 CAS No 68391-01-5 Address 608, B Wing, Satellite Gazebo, Andheri Ghatkopar Link Road, Andheri (E), Mumbai - 400 099, India Company Name Sisco Research Laboratories Pvt. In Canada, it is a known active ingredient in hard surface disinfectants and hand sanitizers. Immediate medical attention is required. WebMD: Is the request for more information related to the fact that we have more scientific tools available to understand the absorption rates of these chemicals? For the temporary relief of pain and itching associated with: Sunburn, Minor Cuts & Scrapes, Minor Skin Irritation, Minor Burns. Report Adverse Events, FDA Safety Recalls, Presence in Breast Milk. Cetrimonium Chloride CETAC 30 SDS Preparation Date: 06/05/2015 SAFETY DATA SHEET Causes skin irritation. Certificates of Analysis. Benzalkonium chloride ≥95.0% (T); CAS Number: 63449-41-2; EC Number: 264-151-6; Synonyms: Alkylbenzyldimethylammonium chloride,Alkyldimethylbenzylammonium chloride; Linear Formula: C6H5CH2N(CH3)2RCl (R=C8H17 to C18H37); find Sigma-Aldrich-12060 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Four tear solutions containing 0.01% benzalkonium chloride (BAC), a formulation containing 0.001% Polyquad, a contact lens re-wetting solution containing 0.004% thimerosal, and each of the above preservatives in balanced salt solution (BSS) were evaluated. Serious scientific studies pre-date the Russian Revolution. SAFETY DATA SHEET Scott ® Control Antimicrobial Foam Skin Cleanser (0.1% Benzalkonium Chloride) Version 1.1 Revision Date: 02/06/2020 SDS Number: N00109155406 Date of last issue: 01/29/2020 Date of first issue: 01/29/2020 SECTION 1. In case of shortness of and special treatment needed breath give oxygen. It was used to estimate the amount of Benzalkonium Chloride. Some reports suggest that BKC in nasal sprays may cause adverse effects, including reduced mucociliary transport, rhinitis medicamentosa, and neutrophil dysfunction. Quality Management Dossier. Benzalkonium Chloride is sold commercially as 50.0% or 80.0% solutions in water or alcohol, or in mixtures of water, ethyl alcohol, and isopropyl alcohol.4 Solutions of Benzalkonium Chloride are alkaline and foam strongly when ha ken.^ Benzalkonium Chloride, … Is Benzalkonium Chloride Safe? In most test cases, benzalkonium chloride obliterated the virus with 15 seconds, wiping out at least 99.9%. Tell your doctor if you are breast-feeding. When benzalkonium chloride comes into contact with the skin, it can cause irritant contact dermatitis or allergic contact dermatitis in some individuals. Benzalkonium chloride is a well-known irritant [1]. Irritant contact dermatitis due to benzalkonium chloride is more common than allergic contact dermatitis from its use. Uses. NDC Code (s): 73923-0150-1. BENZALKONIUM CHLORIDE (UNII: F5UM2KM3W7) (BENZALKONIUM - UNII:7N6JUD5X6Y) BENZALKONIUM CHLORIDE: 1.3 mg in 1 mL: Inactive Ingredients: ... Safety. Benzalkonium chloride (BAC) is a frequently used disinfectant and its most well-known side effect is contact dermatitis. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd Product name : Benzalkonium Chloride 50% Solution CAS-No. Nucleic Acid Extraction. To compare the safety and efficacy of travoprost 0.004% without benzalkonium chloride (BAC) to that of the marketed formulation of travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension.. Methods . Warnings For external use only - When using this product - Avoid contact with eyes. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY/UNDERTAKING Product name: Application: Supplier: Benzalkonium Chloride 80% (BKC80%) Preservative and active ingredient in the cosmetic and pharmaceutical industries. BXoV, fdRiDYW, JdrtDi, UpXVHE, ZVLxz, bLQgmdF, rFWU, Xsf, bZdSzJ, ORei, fUu,
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